Reclaim your vitality during midlife. Developed by Dr Onyx MD PhD (Certified Menopause Practitioner), this integrated protocol addresses the root causes of menopause symptoms by optimizing the Gut-Hormone connection (Estrobolome).

Tired of menopause symptoms hijacking your life? This bundle targets the gut-hormone connection for real relief & renewed energy. Feel like YOU again.

Three physician-designed tools that work together—cleanse, seed, and guide—to steady hormones, calm digestion, and bring your energy back online in mid-life.

A 3-part, physician-designed protocol to calm a sensitive gut, nourish your estrobolome (the gut-hormone axis), and guide you through midlife with confidence.

Why this bundle works

Targets the Gut–Hormone Axis: Reseeds key Lactobacillus, Bifidobacterium and Bacillus species linked to smoother temperature swings, steadier sleep and mood, balanced vaginal flora, more favorable lipid profiles, and healthy weight trajectories during peri/post-menopause.

Gentle for sensitive digestion: Both supplements are Low FODMAP. The synbiotic uses PreforPro® bacteriophage technology (15 mg) instead of large doses of fermentable fibers—so you get benefits without the bloat.

Shelf-stable, travel-ready: Includes DE111® Bacillus subtilis spore-forming probiotic for potency through heat and stomach acid; no refrigeration needed.

Clarity + consistency: A 500+ page Menopause Wellness Guide keeps you on track with practical tools, trackers, and action steps.

What’s inside

1) Advanced Probiotic & Prebiotic Synbiotic

A potent blend of clinically studied probiotics + the revolutionary PreforPro® prebiotic, designed by Dr. Onyx MD PhD to support a resilient microbiome and the gut–brain axis—without digestive discomfort.

FODMAP Friendly, Gut Friendly, Paleo, Keto

PreforPro® inside (15 mg): Selectively targets unwanted bacteria at an ultra-low dose, minimizing gas and bloating common with fiber prebiotics.

4.4 Billion CFU with DE111® (Bacillus subtilis) + B. coagulans, L. acidophilus, B. lactis to restore balance and enhance nutrient absorption.

Quality: Third-party tested, cGMP facility, guaranteed potency.

Ingredients (per capsule):

PreforPro® 15 mg (LH01 – Myoviridae, LL5 – Siphoviridae, T4D – Myoviridae, LL12 – Myoviridae)

Probiotics 4.4 Billion CFU: Bacillus subtilis (DE111®), Bacillus coagulans, Lactobacillus acidophilus, Bifidobacterium lactis

Key benefits

Helps maintain healthy microbiome balance

Digestive comfort without fiber-related bloating

Supports nutrient absorption and immune function

Enhances the effectiveness of co-administered probiotics

2) Advanced Probiotics GI Support

Seven research-backed strains curated for midlife—supporting the estrobolome, temperature swings, sleep quality, metabolic health, endothelial function, bone markers, and vaginal flora.

Low FODMAP capsule with DE111® spore + Lactobacillus/Bifidobacterium blend

Evidence-informed strain roster:

L. acidophilus — RCTs show meaningful reductions in menopausal symptom scores (hot flashes, irritability, sleep disruption).

L. rhamnosus — Supports vaginal comfort by restoring Lactobacillus dominance (lower Nugent scores).

L. paracasei + L. plantarum — Help maintain bone-mineral density and vitamin-D status (gut–bone axis).

B. longum — Improves sleep-quality sub-scores and daytime vitality.

B. breve — Mechanistic support for healthy weight and lipids via estrogen-receptor-β pathways.

DE111® (B. subtilis) — Human data for endothelial function and cholesterol markers.

Supplement Facts (per capsule):

Probiotic bacteria 5.75 Billion CFU (9 mg): DE111® (B. subtilis), L. rhamnosus, L. casei, B. longum, L. acidophilus, L. plantarum, B. breve

Why Low FODMAP matters

No inulin, chicory, FOS, or lactose carriers

Designed to minimize gas, spasms, and bloating—ideal for IBS-prone, elimination-phase, or sensitive guts

3) Menopause Wellness Guide (Digital, 500+ pages)

A comprehensive, beautifully organized set of guides and workbooks covering symptom science, nutrition for menopause, mood & sleep strategies, physical activity plans, and practical worksheets/action steps—so you can personalize your protocol and track progress.

Who it’s for

Peri- and post-menopausal women seeking gut-friendly support for hot flashes, sleep, mood, weight/lipids, vaginal flora, and overall digestive comfort

Anyone who needs Low FODMAP-compatible supplements without bloat-triggering fibers

Busy travelers or on-the-go professionals who want shelf-stable potency

How to use the protocol

Daily (Weeks 1–8):

Morning: 1 capsule Advanced Probiotics GI Support with or without food.

Evening: 1 capsule Advanced Probiotic & Prebiotic Synbiotic with or without food.

Sensitive stomach? Start with one product for 3–5 days, then add the second; or take them at opposite times of day (as above). Consistency matters—most human trials observe changes over 4–8 weeks.

Hydration & habits: Drink water, prioritize protein + fiber from tolerated Low FODMAP sources, and follow the Menopause Wellness Guide worksheets for best results.

What you’ll notice

Calmer digestion and less day-to-day bloat

More stable temperature swings and more restful nights

Steadier mood and energy

Support for healthy lipids, weight trajectory, and vaginal microbiome balance

(Individual responses vary.)

Product quality & standards

FODMAP Friendly (Synbiotic)

Low FODMAP formulation (GI Support)

Third-party tested | cGMP facility | Guaranteed potency

Paleo & Keto compatible | No refrigeration required

Frequently asked questions

What makes the synbiotic different?

Traditional prebiotics rely on grams of fermentable fibers that can cause gas and bloating. Our synbiotic uses PreforPro® bacteriophage technology (15 mg) to selectively target unwanted bacteria while supporting beneficial strains—gentle, effective, Low FODMAP.

Can I take both probiotics together?

Yes. Many users take GI Support in the morning and the Synbiotic in the evening for round-the-clock coverage. If you’re very sensitive, start with one product for a few days and add the second once comfortable.

Is this really Low FODMAP?

Yes. The Synbiotic is Low FODMAP, and GI Support is formulated Low FODMAP (no inulin, chicory, FOS, or lactose carriers).

How long until I feel a difference?

Most notice changes between 2–4 weeks, with fuller benefits by 8 weeks of daily use.

Do I need to refrigerate these?

No—both are shelf-stable. DE111® spore technology protects potency through heat and stomach acid.

Any diet compatibility notes?

Both are suitable for Low FODMAP, Paleo, and Keto lifestyles.

Directions & suggested routine

Take 1 capsule of each daily, separated by several hours (AM/PM).

May be taken with or without food.

Drink water and follow the Menopause Wellness Guide checklists.

If pregnant, nursing, have a medical condition, or take medications, consult your healthcare provider.

Gut Health Supplements

Herbal Laxative 15 Day Colon Cleanse Low FODMAP Gut Friendly Gentle Motility Support

Vitamin & Mineral Gummies | Low FODMAP & GLP-1 Daily Essential Nutrition

The Menopause Gut-Hormone Reset Protocol (MD PhD Formulated)